You will definitely hear a significant difference, anyone would. PA speakers are designed to be as flat as possible to reproduce the sound they are amplifying as accurately as possible. Guitar speakers on the other hand, are specifically designed to color and add tone. ![Smile :) :)](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)