You build your sounds regardless of rig type at gig/practice volume. Doesn't matter if you are using a modeler in to the PA, a Recto half stack, or a Fender twin. +What everyone else has said.
1=High E 8=Low F# (or what ever you want to tune to) Get everything close first and then... 1 2 12 123 1234 12345 123456 1234567 12345678 In other words tune the first string, then the second, then the first and the second, adding another string every time. Seems logical to me, but I don't own...
A graphic eq pedal set flat and a few db below unity gain when the pedal is on in the effects loop would do the job. When you turn it off, you have your solo boost. You could do the same with a clean boost type pedal as well.