Very much so. The XXX Sheffields work better with the 5150 than the XXX but all Peavey speakers seem to be lacking. You are doing your self good by getting a mesa cab of any sort.
they sound sick with 5150s, but they are a touch dark in tone. Personally I loved the combo when i had my 6505+. The low end is a huge and a bit loose, but should be manageable with the right settings